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Metoclopramide is available in several forms including:
• Reglan Tablets
• Reglan Oral Disintegrating Tablets
• Metoclopramide Oral Solution
• Reglan Injection
It is estimated that more than two million people in the United States use these metoclopramide containing products. According to the FDA:
“Recently published analyses suggest that metoclopramide is the most common cause of drug-induced movement disorders. Another analysis of study data by the FDA showed that about 20 percent of patients in that study who used metoclopramide took it for longer than three months. The FDA has also become aware of continued spontaneous reports of tardive dyskinesia in patients who used metoclopramide, the majority of whom had taken the drug for more than three months.”
Metoclopramide has been manufactured in the branded “Reglan” form and the generic form by several different pharmaceutical companies including:
• Wyeth
• Actavis
• ANI Pharmaceuticals
• Baxter
• Hospira/Mayne Pharmaceuticals
• Morton Grove Pharmaceuticals
• URL Pharma
• Qualitest Pharmaceuticals
• Schwarz Pharma
• Teva Pharmaceutical
Reglan acts in the upper end of the digestive system and works by speeding up the movement of the stomach muscles, thus increasing the rate at which the stomach empties into the intestines. It is used as a short-term treatment of gastroesophageal reflux disease in patients who have not responded to other therapies, and to treat diabetic gastroparesis (slowed emptying of the stomach’s contents into the intestines). It is recommended that treatment not exceed twelve weeks, however it is estimated that around thirty percent of patients who are prescribed products containing metoclopramide take the medication for a much longer period of time.
Serious neurologic Reglan drug side effects include:
• ocular deviations
• blepharospasm
• cervical dystonia (torticollis)
• Parkinsonian symptoms
• Akathisia
• neuroleptic malignant syndrome
• tardive dyskinesia
Tardive dyskinesia (TD) is a drug-induced movement disorder caused by the long-term use of neuroleptic drugs. Tardive means “delayed” and dyskinesia means “abnormal movement.” This serious neurological syndrome is often irreversible and may become permanent. Since the 1950’s a family of drugs referred to as dopamine receptor blocking drugs (DRB) have been prescribed for certain mental health conditions and are now also commonly prescribed for the treatment of GERD and nausea. Metoclopramide / Reglan is a dopamine receptor blocking drug.
Article Source: http://www.articlemotron.com
It has recently been reported that drug Metoclopramide (also referred to as Reglan) used to treat gastrointestinal disorders has been linked to the dangerous side effect tardive dyskinesia. On January 26, 2009 the FDA issued an alert warning against chronic use of metoclopramide containing drugs and requiring a boxed warning.
David Johnson is author of this article on Metoclopramide side effects. Find more information about Reglan lawsuit here.
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